Unlike neuromodulation, treatment for severe depression involving ketamine, seems to work quite quickly in lifting patients’ moods.
Studies have shown it to improve moods in patients in as little as a few hours after it’s given.
Ketamine has been used for many years for anesthesia. Some doctors started noticing some of their patients would came out of anesthesia in a much better mood than before they went under. This effect was not just a short term thing either. There were patients who would be in better moods for weeks or months after anesthesia. This led to research on using ketamine to treat depression.
While ketamine has traditionally been administered intravenously, the FDA has approved a version called esketamine that is taken through the nose.
Ketamine has been shown to reduce fatigue and thoughts of suicide as well as improve sleep patterns in those with major depression.
Additional treatments for depression using ketamine are being researched that it is hoped will provide longer lasting effects along with fewer side effects.