191 listed in North Carolina · Listings last verified November 2026 · How we vet listings
We list Spravato treatment centers across North Carolina, mainly in Raleigh–Durham, Greensboro–Winston-Salem and Charlotte (191 in total). Spravato is a nasal spray for hard-to-treat depression. You take it in the office, and staff watch you for at least 2 hours after each dose. Compare the listings below, then call to ask about insurance and openings.
If you're in crisis or thinking about suicide, call or text 988 now [5].
Spravato is given only at certified treatment centers, where you're monitored after each dose. In North Carolina, our list is largest around Raleigh, Greensboro and Charlotte, with a smaller group in Rockingham. We include providers whose own website or Google listing names Spravato, usually psychiatric practices.
Spravato (esketamine) is a prescription nasal spray for depression, made by Johnson & Johnson. It's related to ketamine. It works differently from standard antidepressants [1].
You spray it yourself in a certified clinic, with a provider watching. Then you stay for at least 2 hours so staff can check for side effects like sleepiness, feeling disconnected (dissociation), breathing problems and higher blood pressure [1].
A typical schedule is twice a week for the first 4 weeks, then once a week for weeks 5 to 8. After that, it's once a week or every 2 weeks [1].
Spravato is only available through a safety program called the Spravato REMS. Only certified clinics can give it, and you can't take it home [1][4]. It has a boxed warning about sedation, dissociation, breathing problems, misuse and suicidal thoughts [1].
Spravato is approved for two groups of adults [1]:
It isn't approved for children. It isn't a replacement for a hospital stay when one is needed [1].
You can't take Spravato if you have certain blood vessel problems, such as an aneurysm, or a history of bleeding in the brain [1]. Tell your provider about any past drug or alcohol misuse.
You can't drive or use machinery until the next day, after a restful sleep. Plan for someone to take you home after every visit [1].
If you're having thoughts of suicide, call or text 988 now [5].
Each Spravato visit includes both the medicine and the 2-hour monitoring. What you pay depends on your coverage.
Commercial insurance. Your plan may need to approve Spravato before you start. Ask the center to check your benefits. If you're covered, the Spravato withMe Savings Program can lower your cost to as little as $10 per treatment for the medicine. It doesn't cover the cost of the monitoring time. Yearly limits apply, and the terms reset each calendar year [2].
Medicare. Medicare treats Spravato as a medicine given in the office under a provider's direct supervision, so it's billed as part of your visit rather than picked up at a pharmacy [3]. Ask the center what your Medicare plan will cover and what you'll owe. Manufacturer savings programs can't be used with Medicare, Medicaid, TRICARE or VA coverage [2].
Medicaid. Coverage and approval rules depend on your state's program. Ask the center whether it accepts North Carolina Medicaid.
Travel and time. Each visit takes at least 2 hours plus check-in, and you'll need a ride home. Plan for that during the twice-weekly weeks.
For more on depression treatment options, see our depression guide.
Avance Psychiatry and Pain Management Chapel Hill
Psychiatry
Last verified Nov 2026 Report a correction
GPW Psychiatry
Psychiatry
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Animo Sano Psychiatry- Fortunes Ridge Dr, Durham
Psychiatry
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Psychiatry
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GPW Psychiatry - Clayton
Psychiatry
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GPW Psychiatry - Midtown/North Hills
Psychiatry
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Psychiatry
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Consoling Minds Psychiatry
Psychiatry
Last verified Nov 2026 Report a correction
Swift Creek Mental Health Services Pllc
Psychiatry
Last verified Nov 2026 Report a correction
Cary Behavioral Health
Psychiatry
Last verified Nov 2026 Report a correction
GPW Psychiatry - Midtown/North Hills
Psychiatry
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GPW Psychiatry - Midtown/North Hills
Psychiatry
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Ketamine Wellness Institute (Chapel Hill)
Psychiatry
Last verified Nov 2026 Report a correction
GPW Psychiatry - North Raleigh
Psychiatry
Last verified Nov 2026 Report a correction
Avance Care Behavioral Health at Avance Centers of Excellence
Psychiatry
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Psychiatry
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Psychiatry
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Triangle Mental Health, PLLC
Psychiatry
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Psychiatry
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Cary Behavioral Health
Psychiatry
Last verified Nov 2026 Report a correction
Make sure the center is certified. Spravato can only be given at clinics certified in the Spravato REMS program [1][4]. Every center in our Spravato listings says it offers Spravato, but ask to confirm their REMS certification when you call.
Ask about monitoring. Staff must watch you for at least 2 hours after each dose, including checks on your breathing and blood pressure [1]. Ask where you'll wait, who watches you and what happens if you feel unwell.
Ask who manages your care. A psychiatrist or other prescriber should oversee your whole treatment, including your antidepressant. Ask how they'll measure progress and when they'll review the plan.
Ask about scheduling and costs. Ask how soon you can start, how they handle the twice-weekly weeks and whether they'll help with insurance approval and savings program enrollment.
Confirm the basics yourself. Call to check insurance and new-patient openings. We don't verify these.
Spravato can cause sleepiness, a feeling of being disconnected from yourself, higher blood pressure and, rarely, breathing problems. These effects are strongest soon after the dose. FDA rules require a provider to watch you for at least 2 hours at every session and to check that you're stable before you leave.
No. You can't drive or use machinery until the next day, after a restful sleep. Arrange for a family member, friend or ride service to take you home after every treatment. Many people plan their week around this, especially during the first month when visits are twice a week.
They're closely related. Spravato contains esketamine, one form of the ketamine molecule. Spravato is an FDA-approved nasal spray for depression, given only at certified centers with set monitoring rules. Ketamine infusions for depression are not FDA approved for that use, so the rules and insurance coverage are different.
Coverage depends on your plan, and many plans want to approve it first. With Medicare, Spravato is billed as part of your office visit at a certified center. If you have commercial insurance, the withMe Savings Program can lower your medicine cost to as little as $10 per treatment.
Don't wait. Call or text 988 to reach the Suicide & Crisis Lifeline any time, day or night. It's free and confidential. If you're in immediate danger, call 911 or go to the nearest emergency room. Spravato is not a replacement for emergency or hospital care.