Charlotte Ketamine Center
Psychiatry
- Address
- 3535 Randolph Rd #208, Charlotte 28211
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Spravato Providers in North Carolina
191 listed in North Carolina · Listings last verified November 2026 · How we vet listings
We list Spravato treatment centers across North Carolina, mainly in Raleigh–Durham, Greensboro–Winston-Salem and Charlotte (191 in total). Spravato is a nasal spray for hard-to-treat depression. You take it in the office, and staff watch you for at least 2 hours after each dose. Compare the listings below, then call to ask about insurance and openings.
If you're in crisis or thinking about suicide, call or text 988 now [5].
Spravato is given only at certified treatment centers, where you're monitored after each dose. In North Carolina, our list is largest around Raleigh, Greensboro and Charlotte, with a smaller group in Rockingham. We include providers whose own website or Google listing names Spravato, usually psychiatric practices.
What it is
Spravato (esketamine) is a prescription nasal spray for depression, made by Johnson & Johnson. It's related to ketamine. It works differently from standard antidepressants [1].
You spray it yourself in a certified clinic, with a provider watching. Then you stay for at least 2 hours so staff can check for side effects like sleepiness, feeling disconnected (dissociation), breathing problems and higher blood pressure [1].
A typical schedule is twice a week for the first 4 weeks, then once a week for weeks 5 to 8. After that, it's once a week or every 2 weeks [1].
Spravato is only available through a safety program called the Spravato REMS. Only certified clinics can give it, and you can't take it home [1][4]. It has a boxed warning about sedation, dissociation, breathing problems, misuse and suicidal thoughts [1].
Who it's for
Spravato is approved for two groups of adults [1]:
- Treatment-resistant depression. In the studies behind its approval, this meant depression that hadn't improved enough after at least 2 different antidepressants. Spravato can be used alone or with an antidepressant pill.
- Major depression with suicidal thoughts or actions. Here, it's used with an antidepressant pill.
It isn't approved for children. It isn't a replacement for a hospital stay when one is needed [1].
You can't take Spravato if you have certain blood vessel problems, such as an aneurysm, or a history of bleeding in the brain [1]. Tell your provider about any past drug or alcohol misuse.
You can't drive or use machinery until the next day, after a restful sleep. Plan for someone to take you home after every visit [1].
If you're having thoughts of suicide, call or text 988 now [5].
Cost and coverage
Each Spravato visit includes both the medicine and the 2-hour monitoring. What you pay depends on your coverage.
Commercial insurance. Your plan may need to approve Spravato before you start. Ask the center to check your benefits. If you're covered, the Spravato withMe Savings Program can lower your cost to as little as $10 per treatment for the medicine. It doesn't cover the cost of the monitoring time. Yearly limits apply, and the terms reset each calendar year [2].
Medicare. Medicare treats Spravato as a medicine given in the office under a provider's direct supervision, so it's billed as part of your visit rather than picked up at a pharmacy [3]. Ask the center what your Medicare plan will cover and what you'll owe. Manufacturer savings programs can't be used with Medicare, Medicaid, TRICARE or VA coverage [2].
Medicaid. Coverage and approval rules depend on your state's program. Ask the center whether it accepts North Carolina Medicaid.
Travel and time. Each visit takes at least 2 hours plus check-in, and you'll need a ride home. Plan for that during the twice-weekly weeks.
For more on depression treatment options, see our depression guide.
Charlotte area
Emily Stump, NP
Zen Psychiatric Services, PLLC SPRAVATO® (esketamine) & Ketamine Treatment Center
Psychiatry
- Address
- 137 Professional Park Dr Ste D, Mooresville 28117
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Excel Psychiatric Associates, P.A.
Psychiatry
- Address
- 10225 Hickorywood Hill Ave b, Huntersville 28078
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Foothills Consulting Associates
Psychiatry
- Address
- 1610 E Marion St Ste 250, Shelby 28150
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Geode Health
Psychiatry
- Address
- 5960 Fairview Rd suite 428, Charlotte 28210
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
GPW Psychiatry – Mooresville
Psychiatry
- Address
- 116 Gasoline Aly Dr Ste 105, Mooresville 28117
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Greenbrook Mental Wellness Centers
Psychiatry
- Address
- 6701 Carmel Rd Ste 305, Charlotte 28226
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Greenbrook TMS NeuroHealth Centers
Psychiatry
- Address
- 1111 Circle Dr, Monroe 28112
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Jason E. Mastor, MD
Mastor Mental Health
Psychiatry
- Address
- 206 Joe V Knox Ave Suite F, Mooresville 28117
- Telehealth
- Practice offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Mastor Mental Health
Psychiatry
- Address
- 206 Joe V Knox Ave Ste f, Mooresville 28117
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Mid Carolina Psychiatry
Psychiatry
- Address
- 6719 Fairview Rd, Charlotte 28210
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Mid Carolina Psychiatry, PA
Psychiatry
- Address
- 6719 Fairview Rd, Charlotte 28210
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Mind Fit Behavioral Health Mooresville, NC
Psychiatry
- Address
- 378 Williamson Rd #204, Mooresville 28117
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
MindWell Health Charlotte (SouthPark) – Mental Health, Ketamine, and Spravato
Psychiatry
- Address
- 2700 Coltsgate Rd #106, Charlotte 28211
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Modern Wellness 360 Ketamine Clinic
Psychiatry
- Address
- 10410 Park Rd suite 200 b, Charlotte 28210
- Telehealth
- Not listed
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Natalie A. Errante, PMH-NP
Ultra Violet Mental Health
Psychiatry
- Address
- 1930 Jake Alexander Blvd W Ste 1020, Salisbury 28147
- Telehealth
- Practice offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Pediatric and Family Behavioral Health
Psychiatry
- Address
- 10420 Park Rd Ste 300, Charlotte 28210
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
PsychPlus Charlotte Clinic – Psychiatrist and Therapist
Psychiatry
- Address
- 3541 Randolph Rd Ste 102, Charlotte 28211
- Telehealth
- Offers telehealth
- Medicare
- Accepts Medicare
- Medicaid
- Accepts Medicaid
Last verified Nov 2026 Report a correction
Serenity Psychiatric & Counseling Services
Psychiatry
- Address
- 16930 W Catawba Ave Ste 200, Cornelius 28031
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Not listed
Last verified Nov 2026 Report a correction
Three Strand Wellness and TSW Integrative Psychiatry
Psychiatry
- Address
- 1515 Mockingbird Ln #360, Charlotte 28209
- Telehealth
- Offers telehealth
- Medicare
- Not listed
- Medicaid
- Accepts Medicaid
Last verified Nov 2026 Report a correction
How to choose a provider
Make sure the center is certified. Spravato can only be given at clinics certified in the Spravato REMS program [1][4]. Every center in our Spravato listings says it offers Spravato, but ask to confirm their REMS certification when you call.
Ask about monitoring. Staff must watch you for at least 2 hours after each dose, including checks on your breathing and blood pressure [1]. Ask where you'll wait, who watches you and what happens if you feel unwell.
Ask who manages your care. A psychiatrist or other prescriber should oversee your whole treatment, including your antidepressant. Ask how they'll measure progress and when they'll review the plan.
Ask about scheduling and costs. Ask how soon you can start, how they handle the twice-weekly weeks and whether they'll help with insurance approval and savings program enrollment.
Confirm the basics yourself. Call to check insurance and new-patient openings. We don't verify these.
Frequently asked questions
Why do I have to stay 2 hours after Spravato?
Spravato can cause sleepiness, a feeling of being disconnected from yourself, higher blood pressure and, rarely, breathing problems. These effects are strongest soon after the dose. FDA rules require a provider to watch you for at least 2 hours at every session and to check that you're stable before you leave.
Can I drive after a Spravato treatment?
No. You can't drive or use machinery until the next day, after a restful sleep. Arrange for a family member, friend or ride service to take you home after every treatment. Many people plan their week around this, especially during the first month when visits are twice a week.
Is Spravato the same as ketamine?
They're closely related. Spravato contains esketamine, one form of the ketamine molecule. Spravato is an FDA-approved nasal spray for depression, given only at certified centers with set monitoring rules. Ketamine infusions for depression are not FDA approved for that use, so the rules and insurance coverage are different.
Does insurance cover Spravato?
Coverage depends on your plan, and many plans want to approve it first. With Medicare, Spravato is billed as part of your office visit at a certified center. If you have commercial insurance, the withMe Savings Program can lower your medicine cost to as little as $10 per treatment.
What if I'm in crisis while waiting to start?
Don't wait. Call or text 988 to reach the Suicide & Crisis Lifeline any time, day or night. It's free and confidential. If you're in immediate danger, call 911 or go to the nearest emergency room. Spravato is not a replacement for emergency or hospital care.
Sources
- DailyMed (NLM) — Spravato (esketamine) nasal spray prescribing information (rev. 3/2026)
- Johnson & Johnson — SPRAVATO withMe Savings Program requirements
- First Coast Service Options (Medicare contractor) — SPRAVATO place of service requirements (April 17, 2026)
- SPRAVATO REMS (Risk Evaluation and Mitigation Strategy)
- 988 Suicide & Crisis Lifeline